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What Happens If ADHD is Left Untreated in Adults? Adults with ADHD may experience a variety of issues if the condition is not treated. This includes issues with relationships, work and mental health. Adults with untreated ADHD generally have low self-esteem, and have a negative outlook on the world. This can cause them to feel like they are failures at work and at home. Inattention and lack of Focus Being unable to focus at times is normal, especially after a long day at school or at work. However, if you start to notice that your