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Betalain-rich extracts were utilized for many years by their nutraceutical potential. However, the analysis of the bioactivities has been hampered by their difficult obtention. To describe their particular mode of action, seventeen pure betalains were tested in vivo making use of the pet design C. elegans. Four betalains, named indicaxanthin, indoline carboxylic acid-betacyanin, phenylalanine-betaxanthin, and dopaxanthin, behaved as extraordinary in