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Moreover, the generated reactive oxygen species by photosensitizer Zn-TPPS with light irradiation could obviously block DOX efflux and ultimately induce apoptosis to effectively reverse multidrug resistance of tumor cells. Meanwhile, the combination of photosensitizers and chemotherapies obviously created an enhanced MDR reversal effect, providing a promising approach for MDR reversal to achieve highly efficient cancer therapeutics. V.Large and small wheat starch granules were modified by conventional and pulsed electric fields (PEF)-