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Our analysis provides new clues for a better understanding of the pathogenic mechanisms and offers potential therapeutic targets for osteoporosis. Copyright © 2020 Dong, Zhou, Wang, Zuo, Ying, Chai, Fei, Jin, Chen, Ma and Liu.In the aging western population, the average age of incidence for spinal cord injury (SCI) has increased, as has the length of survival of SCI patients. This places great importance on understanding SCI in middle-aged and aging patients. Axon regeneration after injury is an area of study that has received substanti