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This suggested that extracellular matrix degradation was inhibited by karacoline (P  less then  0.05). Our data therefore reveal a new clinical application of karacoline and provide support for the use of network pharmacology in predicting novel drugs. © 2019 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.Nanodiamonds are novel nanosized carbon building blocks possessing varied fascinating mechanical, chemical, optical and biological properties, making them significant active moiety carriers for biomedical application.