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The decreased cardiac damage in MDSC-depleted mice was associated with fewer Mac3+ macrophages and CD3+ T lymphocytes and a reduced cardiac expression of S100A8, S100A9, IL-1β, IL-6, and TNF-α. In conclusion, impairment of functional NK cells by MDSC promotes the development of chronic CVB3 myocarditis in A.BY/SnJ mice.A review paper is presented on optimization and scale-up for polymer extrusion, both single screw and twin screw extrusion. Optimization consists in obtaining a multidimensional space of process output variables (response
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