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76; 95% CI 0.51, 1.14, p = 0.19) or 6-SNP genetic instruments (OR 0.77; 95% CI 0.48, 1.25, p = 0.29). The result also remains non-significant when using the more liberal 77-SNP instrument. Our findings do not support a causal relationship between coffee intake and NAFLD risk. However, despite the largest-to-date sample size, the power of this study may be limited by the non-specificity and moderate effect size of the genetic alleles on coffee intake. Our findings do not support a causal relationship between coffee intake and NAFLD risk.
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