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The present paper provides an attractive method to prepare chitosan/hyaluronic acid based pH/NIR multi-responsive hybrid microcapsules with excellent photothermal conversion efficiency and biocompatibility, which has great potential in the field of remotely controlled drug delivery.We previously obtained and characterized a novel sulfated derivative of the exopolysaccharides from Enterobacter cloacae Z0206 (SEPS). This study aimed at investigating the effects and mechanism of SEPS against dextran sulfate sodium (DSS) induced intestinal