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ADHD Treatment For Adults Stimulants like methylphenidate and amphetamine can boost the levels of certain brain chemicals. Nonstimulants like atomoxetine or antidepressants work slower than stimulants, but they could be just as helpful. The comorbidity of conditions can affect the response to ADHD medications. Physicians should treat the most severe symptom of any co-occurring disorder first, and then examine whether the ADHD symptoms i