https://www.selleckchem.com/pr....oducts/pf-07265807.h
BACKGROUND Critically ill patients show several pathophysiological alterations that can complicate antibiotic dosing. Hence, there is a strong rationale to individualize anti-infective dosing in these patients by utilizing therapeutic drug monitoring (TDM). The current study aimed to develop and validate a liquid chromatography-tandem mass spectrometry method for the simultaneous determination of total and unbound plasma concentrations of three commonly used antibiotics (meropenem, imipenem/cilastatin, and cefoperazone/sulbactam) in
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