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National and international funding agencies should invest in LMIC population neuroscience in order to promote replication and generalization of research from high-income countries.Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that alternate between mania and hypomania or between depression and mixed states, often associated with functional impairment. Although effective pharmacological and non-pharmacological treatments are available, several patients with BD remain symptomatic. The advance in the un