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Results  The genotype and allele frequencies of the CTLA-4 (+49A/G) polymorphism were significantly different between the patients and controls ( p  = 0.00013 and 0.0002, respectively). In particular, the frequency of the G allele, GG homozygous genotype, and AG heterozygous genotype were significantly increased in patients than in controls ([28% versus 7%, odds ratio (OR) = 5.16, 95% confidence interval [CI] = 2.77-9.65, p  = 0.00] [12% versus 2%, OR = 6.68, CI = 1.46-30.69, p  = 0.01] [32% versus 10%, OR = 4.24, CI = 1.95-9.21, p  =