https://www.selleckchem.com/pr....oducts/bms-986165.ht
an Society for Microbiology.During human immunodeficiency virus (HIV-1) entry into cells, the viral envelope glycoprotein (Env) trimer ((gp120/gp41)3) binds receptors, CD4 and CCR5, and fuses the viral and cell membranes. CD4 binding changes Env from a pre-triggered (State-1) conformation to more "open" downstream conformations. BMS-806 blocks CD4-induced conformational changes in Env important for entry and is hypothesized to stabilize a State-1-like Env conformation, a key vaccine target. Here, we evaluate the effects of BMS-806 on
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