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The dataset we provide will be a valuable resource for understanding the combinatorial interactions of RBPs with RNAs and the resulting regulatory outcomes. Autologous facial fat grafting has gained popularity in recent years and is considered to be safe. We present the case of a patient who died due to massive cerebral micro fat embolism after facial fat grafting. Raising awareness and providing more evidence on prevention and treatment of this potentially lethal complication of facial fat grafting. A detailed report was made of the case.