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hose conceived via IVF were at greater risk of developing cancer compared with children conceived naturally. This study found that among children with birth defects, those conceived via IVF were at greater risk of developing cancer compared with children conceived naturally. Genomic screening for hereditary breast and ovarian cancer (HBOC) in unselected women offers an opportunity to prevent cancer morbidity and mortality, but the potential clinical impact and cost-effectiveness of such screening have not been well studied. To estimate