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ADHD Treatment For Adults - Stimulant Medication Stimulant drugs like methylphenidate and dextroamphetamine are generally considered as the first line treatment for adults with ADHD. These drugs balance and boost levels of brain chemicals, known as neurotransmitters. Antidepressants and nonstimulant medications like atomoxetine can be prescribed if stimulants aren't appropriate for the patient due to health issues or adverse reactions. These medications have a slower effect than stimulants, and t