https://www.selleckchem.com/pr....oducts/tetramisole-h
This review is covering the recent development of catalytic asymmetric domino reactions for the desymmetrization of alkene-, alkyne- and allene-tethered cyclohexadienones using transition metals and chiral ligands. This desymmetrization has emerged as an important strategy for the rapid construction of complex molecular skeletons, such as fused-polycycles or spirocyclic compounds in controlling multiple stereogenic centers.Sampling of the vast conformational landscape of organic compounds remains a challenging task in computatio
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