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ADHD Treatment For Adults Stimulants like methylphenidate, amphetamine and various brain chemicals can help increase levels. Nonstimulants, such as antidepressants and atomoxetine, work more slowly than stimulants but they can be beneficial too. Comorbid conditions often affect the effectiveness of ADHD medication. The most serious symptom of any comorbid condition must be treated first. Then, the doctor should monitor whether ADHD symptoms improve. Medication Adults with ADHD are most often treated by medication. There are a variety of medication available to tr