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ADHD Treatment For Adults - Stimulant Medication Stimulant drugs like methylphenidate and dextroamphetamine are typically considered the as the first line treatment for adults with ADHD. These drugs boost and balance neurotransmitters in the brain. Nonstimulant medications such as atomoxetine or antidepressants can be prescribed if stimulants aren't appropriate for the patient because of other health issues or adverse effects. work mor