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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression People who suffer from untreated ADHD often suffer chronic underachievement, which can cause feelings of despair and depression. This is especially evident when they fail to achieve their professional and personal goals. It are difficult to establish when there are symptoms that overlap between ADHD and depression. Identifying the symptoms is the first step to getting treatment. 1. Feelings of inadequateness Untreated ADHD and co-occurring disorders like depression can lea