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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can result in chronic underachievement and depression. This is especially true when they don't achieve their goals in terms of personal and professional. Overlapping symptoms of comorbid ADHD and depression can make it difficult to determine a precise diagnosis. Identifying the symptoms is a good first step in seeking treatment. 1. Feelings of inadequacy Untreated ADH