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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can result in chronic underachievement and depression. This is especially the case when they fail to achieve their professional and personal goals. The overlapping symptoms of the comorbidities of ADHD and depression can make it challenging to get an accurate diagnosis. However, identifying the symptoms is the first step to finding treatment. 1. Feelings of