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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can cause chronic underachievement and depression. This is especially true when they fail to meet their professional and personal goals. Diagnoses can be difficult to make when there are symptoms that overlap between ADHD and depression. Finding the signs is a good first step in seeking treatment. 1. Feelings of inadequacy Many people who have untreated ADHD or co-occurring depress