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First Line Treatment For ADHD in Adults Certain people suffering from ADHD discover that medication can help to manage their symptoms. Stimulants such as methylphenidate or amphetamine work by increasing brain activity in areas that control attention and behavior. Other medications, such as the nonstimulant drug atomoxetine, and some antidepressants work differently, but are still effective. Regular visits to the GP are recommended for people who take medications. They can adjust dosages and check for body reactions. Medication Adults typically receive medica