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Burn injuries (BIs) due to scalding are one of the most common accidents among children. BIs greater than 40% of total body surface area are considered extensive and result in local and systemic response. We sought to assess morphological and myogenic mechanisms through both short- and long-term intensive insulin therapies that affect the skeletal muscle after extensive skin BI in young rats. Wistar rats aged 21d were distributed into four groups control (C), control with insulin (C+I), scald burn injury (SI), and SI with insulin (SI+I).