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© 2020 The Authors. Journal of Parenteral and Enteral Nutrition posted by Wiley Periodicals, Inc. with respect to American Society for Parenteral and Enteral Nutrition.A book peptide stapling strategy effected by a double thiol-ene reaction between two cysteine residues and a divinyl diester to access stapled peptides with enhanced mobile permeability is reported. This diverse substance device kit provides facile access to stapled peptides with vary