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Copyright © 2020 Mahmoud, Sapare, Curry, Demuth and Steinbach-Rankins.The interferon (IFN)-stimulated gene product 15 (ISG15) represents an ubiquitin-like necessary protein (Ubl), which in a process termed ISGylation is covalently linked to target substrates via a cascade of E1, E2, and E3 enzymes. Furthermore, ISG15 exerts functions with its free form both, as an intracellular and also as a secreted necessary protein. In contract along with its role as a kind We IFN effector, man
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