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gume and nuts intake with odds of breast cancer support the current recommendations on these foods. Prospective studies are needed to further examine this link.Introduction The aim of this study was to evaluate the methylation status of TNF-α and SOCS3 promoters in patients with BD and compare them with a healthy group.Method This was a case-control study, in which 47 subjects with BD and 61 individuals as the control participated. Blood samples were collected from all the participants. Then, PBMCs were isolated using the Ficoll method