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Spinal muscular atrophy (SMA) is an inherited lower motor neuron disease. SMA occurs secondary to alterations in the survival motor neuron 1 gene (SMN1), which is the main driver of SMN protein production. The severity of the disease is determined by the number of copies of the SMN2 gene, which is a homolog to SMN1 but not as efficient in protein production. Three medications have recently been approved for the treatment of SMA. Nusinersen is an intrathecal antisense oligonucleotide that alters SMN2 pre-mRNA, onasemnogene abeparvovec-xio

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How to Choose an Electric Incline Treadmill An incline treadmill provides low-impact training for your lower body muscles and can burn calories faster than walking. Which one is best for you? An incline trainer takes up more space and is typically more expensive than a basic treadmill. This model is cost-effective and folds easily thanks to a revolutionary hydraulic folding mechanism. It also comes with 12 preset training plans and connects to apps for virtual training. Motor Vehicles The moto