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7% of AAPCs for colon cancer and 2.0% for rectal cancer. A slight decline was observed in colon and rectal cancers during 2005-2015, regardless of age at diagnosis. A slight decline was observed in colon and rectal cancers during 2005-2015, regardless of age at diagnosis. Accumulating evidence indicates a plausible association between inflammatory bowel diseases and the risk of adverse health outcomes. However, the conclusions are inconsistent. We aimed to perform an umbrella review of meta-analyses to appraise and gra