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This research had been designed to explore the role of EPAS1 into the expansion of erythroblasts in CMS. Changes of HIF-1α and EPAS1/HIF-2α within the bone tissue marrow erythroblasts of 21 patients with CMS and 14 control topics living in the exact same altitudes were based on RT-qPCR and western blotting. We also created a lentiviral vector, Lv-EPAS1/sh-EPAS1, to over-express/silence EPAS1 in K562 cells. Cells period and proliferation had bee