https://nur77signal.com/index.....php/improving-the-ap
Right here, we applied parallel chemoproteomic systems to discover the method of action of clemastine and observe that clemastine binds towards the Plasmodium falciparum TCP-1 band complex or chaperonin containing TCP-1 (TRiC/CCT), an essential heterooligomeric complex required for de novo cytoskeletal protein folding. Clemastine destabilized all eight P. falciparum TRiC subunits based on thermal proteome profiling (TPP). Additional analysis utilizing security
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