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Adult ADHD and Comorbid Disorders Many adults with ADHD also suffer from comorbid disorders, such as major depression (Kessler and colleagues, 2006). Many patients who are depressed do not respond well to medications and may get better results from therapy. Neurotransmitters are brain chemicals that regulate and boost levels of certain brain chemicals. Drugs that stimulate the brain such as methylphenidate or amphetamine are frequently prescribed. Medications Adults can use many medications that are used for ADHD in children. However the dosages differ and th