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BACKGROUND Hypersensitivity reactions (HSR) to antineoplastic agents may lead to discontinuation of first-line treatments. Rapid drug desensitization (RDD) allows for a safe reintroduction in allergic patients. OBJECTIVE To evaluate the safety and efficacy of the Brigham and Women's Hospital's 12-step RDD in a Portuguese cancer patient population, and to identify markers associated with breakthrough reactions (BTR) to platins. METHODS We have conducted a retrospective review of desensitizations undertaken at the Immunoallergology Day-Ca
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