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Further research into epigenetic method might provide us with new eyesight in to the pathogenesis of diabetes mellitus and related problem thus leading to the breakthrough of new healing goals. In this review, we discuss the feasible epigenetic changes and method that happen in diabetic issues mellitus type 1 and kind 2 independently. We highlight the important epigenetic and non-epigenetic therapeutic objectives mixed up in management of diabetic issues and associated com