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Acute and chronic THC exposure have contrasting and regionally specific effects on CBF. While acute THC causes a general escalation in CBF when you look at the anterior cingulate cortex, front cortex and insula, in a dose-dependent way, persistent cannabis use leads to a complete decrease in CBF, especially in the prefrontal cortex, which might be corrected upon prolonged abstinence from the drug. Future researches should focus on s
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