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Stimulant Vs Non Stimulant ADHD Medication Stimulants are the most popular type of prescription medication healthcare providers employ to treat ADHD. These drugs target specific chemical substances in the brain, including dopamine and norepinephrine, to reduce symptoms like inattention and impulsivity. Nonstimulant medicines are second-line treatments for people who do not respond to stimulants. They also have fewer adverse effects. They target v