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From many years ago, gastric lavage has been one of the main pillars of the classic treatment for upper gastrointestinal bleeding (UGI. The present study investigated the effect of gastric lavage with hemostatic powder on the UGIB complications. This clinical trial study was performed on 54 patients who referred to the emergency department during 2017-2018. The subjects were divided into two groups (n=27 per group). Gastric lavage with saline and hemostasis powder was performed in the control and experimental groups, respectively. The