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Adult ADHD and Comorbid Disorders Many adults suffering from ADHD also have comorbid disorders like major depression (Kessler and colleagues 2006). Many people who suffer from depression do not respond well to medications and may be able to benefit from therapy. Medications that most effectively improve the most fundamental symptoms of ADHD seem to boost and regulate levels of certain neurotransmitters, which are brain chemicals. The most commonly prescribed stimulants are methylphenidate, amphetamine and other similar medications. Medi