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The Most Effective ADHD Medication For Adults Stimulants are the first choice of treatment for adults suffering from ADHD. They regulate the levels of two chemical messages in the brain that regulate the attention. Strattera (atomoxetine) is the most effective medication for adhd available for adults. It is available in capsules that can be taken with food or without. Most people find it efficient. It also lasts longer than the more sedatives, like methylphenidate or amphetamine. 1. Strattera Stratte