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05), namely C12 0, C16 0, C17 0, C18 1n9 and C22 1n9. Saturates%, unsaturates%, mono-unsaturates% and saturates/unsaturates were also different between C and K group (P less then 0.05). Of note, C18 1n9/C12 0 and C18 1n9/C22 1n9 in K group were significantly higher than those in controls on 7 d pre-partum (P less then 0.05). It is suggested that the ratios show potential as indicators for prediction of ketosis.Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidored