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Previous monitoring at Great Bay National Wildlife Refuge (NWR), Newington, New Hampshire documented high prevalence of amphibian malformations at sites contaminated with potential endocrine active compounds. In the present study, a combination of in situ and laboratory experiments were used to determine whether contaminants present in the sites affect amphibian growth and reproductive development. Wood frog (Rana sylvatica) tadpoles were exposed in situ at four sites (Ferry Way, Beaver Pond, Lower Peverly, and Stubbs Pond) at Great Ba