https://www.selleckchem.com/pr....oducts/3-amino-9-eth
In the subgroup of patients with known somatic RB1 alterations (n=11), seven of nine somatic mutations were detected (median allele fraction 6.7%). In patients without identified somatic RB1 alterations (n=8), six candidate variants were identified for seven patients. Despite small tumor size, blood-ocular barrier, poor ctDNA blood release and limited plasma sample volumes, we confirm that it is possible to detect ctDNA with high-deep NGS in plasma from patients with intraocular non-hereditary retinoblastoma. This may a