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ADHD Treatment For Adults Stimulants like methylphenidate and amphetamine can boost the levels of certain brain chemicals. Nonstimulants like atomoxetine or antidepressants perform slower than stimulants but they may be just as helpful. Comorbid conditions often affect the effectiveness of ADHD medication. The most severe symptom from any comorbidity should be treated first. Then, the physician must monitor whether ADHD symptoms improve. Medication Medication is the most popular treatment opti