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These results contribute to understanding the effects of contaminants of rising issue and microplastics on aquatic organisms.Toxoplasmosis is a very common parasitic disease caused by Toxoplasma gondii. Limitations of readily available treatments motivate the seek out much better therapies for toxoplasmosis. In this study, we synthesized a few new imidazole derivatives bis-imidazoles (compounds 1-8), phenyl-substituted 1H-imidazoles (compounds 9-19), and thiopen

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Titrating analgesic and sedative drugs in pediatric intensive care remains a challenge for caregivers due to the lack of pharmacodynamic knowledge in this population. The aim of the current study is to explore the concentration-effect relationship for morphine-associated oversedation after cardiac surgery in children aged 3 months to 3 years. Data on morphine dosing, as well as morphine plasma concentrations, were available from a previous study on the pharmacokinetics of morphine after cardiac surgery in children. Oversedation was defi