https://cp526555agonist.com/st....andardization-with-t
All AChRs that work as ligand-gated ion networks tend to be formed from five homologous subunits organized to form a central cation station whose opening is regulated by ACh bound at extracellular subunit interfaces. nAChR subtype subunit composition ranges from α7 homomers to α4β2α6β2β3 heteromers. Subtypes differ in affinities for ACh as well as other agonists like nicotine as well as in efficiencies with which their stations tend to be established and desensitized. Subtyp