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Globally, 4million infants die in their first 4weeks of life every year; above 8million infants died before their first year of birthday, and nearly 10million children died before their 5th birthday. Majority of the deaths were occurred at home because of not receiving health care. In Ethiopia, 120,000 infants died during their first 4 weeks of life. The aim of this study was to assess maternal knowledge about neonatal danger signs and its associations after they had been thought by health professionals in Ethiopia. This study used the