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To conclude, minocycline and starch-desferal decrease mitochondrial dysfunction and severe liver damage after APAP overdose, suggesting that the MPT is probably brought about by metal uptake into mitochondria through MCU. In vivo, minocycline and minocycline plus NAC posttreatment after APAP protect at later on time points than NAC alone, showing that minocycline has a lengthier window of effectiveness than NAC. BACKGROUND Concanavalin A (ConA) is a well-established design to cause autoimmune hepatitis (AIH) in mice which imitates path
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