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How Does Medication For ADHD Work? Stimulants improve your ability to concentrate and control impulses by increasing the levels dopamine and norepinephrine in your brain. They are available in immediate-release (short acting) and extended release tablets, which are taken every day in the morning. Nonstimulant drugs have a longer time to work, but they can also enhance attention and impulse control. Atomoxetine, Viloxazine and guanfacine are antidepressants that raise levels of norepinephrine. Sti