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The outcome associated with child years guide exposure on adult individuality: Data from the United States, European countries, plus a large-scale organic research. CONCLUSIONS A multiple biomarker approach might be useful for predicting postoperative mid-term mortality in patients with severe AS undergoing SAVR. Further large-scale prospective validation should be performed. AJCC 8th Edition of Cancer Staging Manual has now incorporated depth of invasion (DOI) into the clinical st